A

• AR&D - Automated rendezvous and docking

B

C

• C3PO - Commercial Crew and Cargo Program Office
• CCDev - Commercial Crew Development
• COTS - Commercial Off-The-Shelf (traditional)
• COTS - Commercial Orbital Transportation Services (NASA)
• COTS-D - Commercial Orbital Transportation Services - Capability D (human spaceflight)
• CRS - Commercial Resupply Services

D

• DoD - Department of Defense
• DoE - Department of Energy

E

• ECDP - ESMD Commercial Development Policy
• EELV - Evolved Expendable Launch Vehicle
• ESMD - Exploration Systems Mission Directorate
• ETO - Earth to Orbit

F

• FAA - Federal Aviation Administration
• FEM - Finite Element Method
• FOD - Foreign object damage

G

• GEO - Geostationary orbit
• GPS - Global Positioning System

H

• HEO - Highly elliptical orbit
• HSF - Human spaceflight

I

• ICAO - International Civil Aviation Organization
• IP - Intellectual Property
• ISS - International Space Station
• ISDC - International Space Development Conference
• ITAR - International Traffic in Arms Regulations

J

• JSC - Johnson Space Center

K

• KSC - Kennedy Space Center

L

• LEAG - Lunar Exploration Analysis Group 
• LEO - Low Earth orbit

M

• MEO - Medium Earth orbit
• MPLM - Multi-purpose logistics module
• MSS - Masten Space Systems

N

• NASA - National Aeronautics and Space Administration
• NLSI - NASA Lunar Sciences Institute
• NSS - National Space Society
• NSS - National Space Symposium (SF Conference)
• NSSO - National Security Space Office
• NTSB - National Transportation Safety Board

O

• ORS - Operationally Responsive Space

P

• PCM - Pressurized cargo module

Q

R

• RAND - Reasonable and Non-Discriminatory
• RCM - Return cargo module
• RCS - Reaction control system
• R&D - Research and development
• RLV - Reusable launch vehicle

S

• SF - Space Foundation
• SFF - Space Frontier Foundation
• SLC - Space Launch Complex
• SM - Service module
• SSA - Space situational awareness
• SSTO - Single-stage-to-orbit
• STEM - Science, Technology, Engineering, & Mathematics (fields of education)

T

• TSTO - Two-stage-to-orbit

U

• UCM - Unpressurized cargo module
• ULA - United Launch Alliance
• USAF - United States Air Force

V

• VC - Venture capital

W

X

Y

Z